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Cartilage repair in the clinic.
Total joint arthroplasty is used in the treatment of end-stage joint disease. However, many patients with osteoarthritis of the knee require arthroscopic surgery for the treatment of lesions that are otherwise amenable to treatment using arthroscopic surgery. This article reviews current concepts of cartilage repair and the surgical technique of arthroscopic microfracture in the knee. The long-term outcome data are also reviewed. The use of bone marrow stimulation in the treatment of osteoarthritis is also discussed.The present invention is directed to methods and compositions for the treatment of inflammation of the lung and airways. This invention relates to the use of mometasone furoate for the treatment of inflammation of the lung and airways and methods of making the same.
Inflammation of the lung and airways is a complex process mediated by both humoral and cellular mechanisms. The initial acute phase of the inflammatory response is characterized by blood flow to the site of inflammation, vasodilation of the bronchial and pulmonary vasculature, increased vascular permeability, and migration of plasma and cells into the extravascular compartment of the lung. The acute response is generally self-limiting and is associated with increased bronchial and pulmonary hyperreactivity to contractile agonists and enhanced bronchial responsiveness to mediators, but is followed by an accelerated phase of recovery. The continued presence of inflammatory cells in the lung, however, leads to formation of in situ granulation tissue. The granulation tissue is formed by fibroblasts which in response to mediators produced by the inflammatory cells, produce collagen and other extracellular matrix components and express increased numbers of contractile proteins, including myofibroblasts. The fibroblasts are contractile, and in addition to depositing extracellular matrix, contract granulation tissue and other tissues, they also exert a profound influence on the respiratory tract structure and function. It is this process of contraction and remodeling which leads to the long term consequences of scar formation, resulting in narrowing of the airways and loss of normal elastic recoil of the lung. The chronic response is characterized by cellular and matrix alterations in the bronchial and pulmonary parenchyma including the ac619d1d87
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